› 3ez3

X-ray diffraction
2.3Å resolution

Crystal Structure of Plasmodium vivax geranylgeranylpyrophosphate synthase PVX_092040 with zoledronate and IPP bound

Released:
DOI: 10.2210/pdb3ez3/pdb
PDB entry 3ez3 coloured by chain, front view.
PDB entry 3ez3 coloured by chain, side view.
PDB entry 3ez3 coloured by chain, top view.
Source organism: Plasmodium vivax
Entry authors: Wernimont AK, Lew J, Zhao Y, Kozieradzki I, Cossar D, Schapira M, Bochkarev A, Arrowsmith CH, Bountra C, Weigelt J, Edwards AM, Hui R, Artz JD, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-107670 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Farnesyl pyrophosphate synthase, putative Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 396 amino acids
Theoretical weight: 46.22 KDa
Source organism: Plasmodium vivax
Expression system: Escherichia coli
UniProt:
  • Canonical: A5K4U6 (Residues: 1-375; Coverage: 100%)
Gene name: PVX_092040
Sequence domains: Polyprenyl synthetase
Structure domains: Farnesyl Diphosphate Synthase

Ligands and Environments

5 bound ligands:
Ligand ZOL 4 x ZOL
Ligand IPE 4 x IPE
Ligand MG 12 x MG
Ligand EDO 2 x EDO
Ligand GOL 3 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F1
Spacegroup: P212121
Unit cell:
a: 111.266Å b: 109.696Å c: 139.529Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.229 0.226 0.291
Expression system: Escherichia coli

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