› 3mav

X-ray diffraction
2.1Å resolution

Crystal structure of Plasmodium vivax putative farnesyl pyrophosphate synthase (Pv092040)

Released:
DOI: 10.2210/pdb3mav/pdb
PDB entry 3mav coloured by chain, front view.
PDB entry 3mav coloured by chain, side view.
PDB entry 3mav coloured by chain, top view.
Source organism: Plasmodium vivax Sal-1
Primary publication:
Molecular characterization of a novel geranylgeranyl pyrophosphate synthase from Plasmodium parasites.
Artz JD, Wernimont AK, Dunford JE, Schapira M, Dong A, Zhao Y, Lew J, Russell RG, Ebetino FH, Oppermann U, Hui R
OpenAccess logo J Biol Chem 286 3315-22 (2011)
PMID: 21084289

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-107670 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Farnesyl pyrophosphate synthase, putative Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 395 amino acids
Theoretical weight: 46.08 KDa
Source organism: Plasmodium vivax Sal-1
Expression system: Escherichia coli
UniProt:
  • Canonical: A5K4U6 (Residues: 1-375; Coverage: 100%)
Gene name: PVX_092040
Sequence domains: Polyprenyl synthetase
Structure domains: Farnesyl Diphosphate Synthase

Ligands and Environments

1 bound ligand:
Ligand SO4 9 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: P21
Unit cell:
a: 83.969Å b: 116.39Å c: 92.416Å
α: 90° β: 116.01° γ: 90°
R-values:
R R work R free
0.229 0.228 0.262
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Bisphosphonates: the first 40 years.
Russell RG. (2011)
8 more

5 mentions without citation

Molecular characterization of a novel geranylgeranyl pyrophosphate synthase from Plasmodium parasites.
Artz et al. (2011)
4 more