› 3o8p

X-ray diffraction
2.1Å resolution

Conformational plasticity of p38 MAP kinase DFG motif mutants in response to inhibitor binding

Released:
DOI: 10.2210/pdb3o8p/pdb
PDB entry 3o8p coloured by chain, front view.
PDB entry 3o8p coloured by chain, side view.
PDB entry 3o8p coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Namboodiri HV, Karpusas M, Bukhtiyarova M, Springman EB

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172487 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase 14 Chain: A
Molecule details ›
Chain: A
Length: 360 amino acids
Theoretical weight: 41.29 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q16539 (Residues: 1-360; Coverage: 100%)
Gene names: CSBP, CSBP1, CSBP2, CSPB1, MAPK14, MXI2, SAPK2A
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand BMU 1 x BMU
Ligand BOG 1 x BOG
Ligand EDO 1 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P212121
Unit cell:
a: 65.931Å b: 73.587Å c: 76.828Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.218 0.213 0.276
Expression system: Not provided

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