› 3oay

X-ray diffraction
1.95Å resolution

A non-self sugar mimic of the HIV glycan shield shows enhanced antigenicity

Released:
DOI: 10.2210/pdb3oay/pdb
PDB entry 3oay coloured by chain, front view.
PDB entry 3oay coloured by chain, side view.
PDB entry 3oay coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A nonself sugar mimic of the HIV glycan shield shows enhanced antigenicity.
Doores KJ, Fulton Z, Hong V, Patel MK, Scanlan CN, Wormald MR, Finn MG, Burton DR, Wilson IA, Davis BG
Proc Natl Acad Sci U S A 107 17107-12 (2010)
PMID: 20852065

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-213345 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Fab 2G12, light chain Chains: K, L
Molecule details ›
Chains: K, L
Length: 213 amino acids
Theoretical weight: 23.2 KDa
Source organism: Homo sapiens
Expression system: Not provided
Structure domains: Immunoglobulins
Fab 2G12, heavy chain Chains: H, M
Molecule details ›
Chains: H, M
Length: 224 amino acids
Theoretical weight: 23.85 KDa
Source organism: Homo sapiens
Expression system: Not provided
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
Ligand MLI 2 x MLI
Ligand BDF 2 x BDF
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.3
Spacegroup: P212121
Unit cell:
a: 77.905Å b: 93.258Å c: 169.602Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.184 0.182 0.223
Expression system: Not provided

Quick links

Citations

14 review citations

Structural insights into key sites of vulnerability on HIV-1 Env and influenza HA.
Julien et al. (2012)
13 more

2 mentions without citation

A nonself sugar mimic of the HIV glycan shield shows enhanced antigenicity.
Doores et al. (2010)
1 more