› 3oix

X-ray diffraction
2.4Å resolution

Crystal structure of the putative dihydroorotate dehydrogenase from Streptococcus mutans

Released:
DOI: 10.2210/pdb3oix/pdb
PDB entry 3oix coloured by chain, front view.
PDB entry 3oix coloured by chain, side view.
PDB entry 3oix coloured by chain, top view.
Source organism: Streptococcus mutans
Primary publication:
Structure of the putative dihydroorotate dehydrogenase from Streptococcus mutans.
Liu Y, Gao ZQ, Liu CP, Xu JH, Li LF, Ji CN, Su XD, Dong YH
Acta Crystallogr Sect F Struct Biol Cryst Commun 67 182-7 (2011)
PMID: 21301083

Function and Biology Details

Reaction catalysed: 
(S)-dihydroorotate + fumarate = orotate + succinate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
homo tetramer
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184240 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dihydroorotate dehydrogenase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 345 amino acids
Theoretical weight: 37.97 KDa
Source organism: Streptococcus mutans
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8DVA1 (Residues: 1-311; Coverage: 100%)
Gene names: SMU_595, pyrD
Sequence domains: Dihydroorotate dehydrogenase
Structure domains:

Ligands and Environments


Cofactor: Ligand FMN 4 x FMN
1 bound ligand:
Ligand GOL 4 x GOL
1 modified residue:
Ligand MLY 28 x MLY

Experiments and Validation Details

Entry percentile scores
X-ray source: BSRF BEAMLINE 3W1A
Spacegroup: C2221
Unit cell:
a: 103.126Å b: 158.276Å c: 193.351Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.204 0.202 0.248
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 citation in other articles

The disinfection of impression materials by using microwave irradiation and hydrogen peroxide.
Choi et al. (2014)
2 more

2 mentions without citation

Structure of the putative dihydroorotate dehydrogenase from Streptococcus mutans.
Liu et al. (2011)
1 more