› 3zjz

X-ray diffraction
2.92Å resolution

Open-form NavMS Sodium Channel Pore (with C-terminal Domain)

Released:
DOI: 10.2210/pdb3zjz/pdb
PDB entry 3zjz coloured by chain, front view.
PDB entry 3zjz coloured by chain, side view.
PDB entry 3zjz coloured by chain, top view.
Source organism: Magnetococcus marinus MC-1
Primary publication:
Role of the C-terminal domain in the structure and function of tetrameric sodium channels.
Bagnéris C, Decaen PG, Hall BA, Naylor CE, Clapham DE, Kay CW, Wallace BA
OpenAccess logo Nat Commun 4 2465 (2013)
PMID: 24051986

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-106115 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ion transport domain-containing protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 149 amino acids
Theoretical weight: 16.84 KDa
Source organism: Magnetococcus marinus MC-1
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: A0L5S6 (Residues: 130-274; Coverage: 53%)
Gene name: Mmc1_0798
Sequence domains:
Structure domains: Helix Hairpins

Ligands and Environments

3 bound ligands:
Ligand 2CV 4 x 2CV
Ligand 12P 3 x 12P
Ligand NA 5 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: C2221
Unit cell:
a: 80.15Å b: 334.38Å c: 80.21Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.259 0.257 0.287
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

7 review citations

Emerging Diversity in Lipid-Protein Interactions.
Corradi et al. (2019)
6 more

15 mentions without citation

Bacterial voltage-gated sodium channels (BacNa(V)s) from the soil, sea, and salt lakes enlighten molecular mechanisms of electrical signaling and pharmacology in the brain and heart.
Payandeh et al. (2015)
14 more