Function and Biology Details
Reaction catalysed:
Acetylcholine + H(2)O = choline + acetate
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
Fasciculin-2 and Acetylcholinesterase (preferred)
PDBe Complex ID:
PDB-CPX-142974 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Acetylcholinesterase
Molecule details ›
Chain: A
Length: 542 amino acids
Theoretical weight: 59.45 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains: Carboxylesterase family
Structure domains: alpha/beta hydrolase
Length: 542 amino acids
Theoretical weight: 59.45 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical:
P22303 (Residues: 33-574; Coverage: 93%)
Sequence domains: Carboxylesterase family
Structure domains: alpha/beta hydrolase
Fasciculin-2
Molecule details ›
Chain: B
Length: 61 amino acids
Theoretical weight: 6.77 KDa
Source organism: Dendroaspis angusticeps
UniProt:
Structure domains: CD59
Length: 61 amino acids
Theoretical weight: 6.77 KDa
Source organism: Dendroaspis angusticeps
UniProt:
- Canonical: P0C1Z0 (Residues: 1-61; Coverage: 100%)
Structure domains: CD59
Ligands and Environments
No modified residues
Experiments and Validation Details
X-ray source:
NSLS BEAMLINE X4C
Spacegroup:
R32
Expression system: Homo sapiens
