› 4hjs

X-ray diffraction
1.22Å resolution

Kinetic stabilization of transthyretin through covalent modification of K15 by (E)-N-(4-(4-hydroxy-3,5-dimethylstyryl)ethanesulfonamide

Released:
DOI: 10.2210/pdb4hjs/pdb
PDB entry 4hjs coloured by chain, front view.
PDB entry 4hjs coloured by chain, side view.
PDB entry 4hjs coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Stilbene vinyl sulfonamides as fluorogenic sensors of and traceless covalent kinetic stabilizers of transthyretin that prevent amyloidogenesis.
Suh EH, Liu Y, Connelly S, Genereux JC, Wilson IA, Kelly JW
J Am Chem Soc 135 17869-80 (2013)
PMID: 24180271

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136168 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chains: A, B
Molecule details ›
Chains: A, B
Length: 116 amino acids
Theoretical weight: 12.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02766 (Residues: 30-145; Coverage: 91%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family
Structure domains: Transthyretin/hydroxyisourate hydrolase domain

Ligands and Environments

1 bound ligand:
Ligand 18J 2 x 18J
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: P21212
Unit cell:
a: 42.522Å b: 85.747Å c: 63.373Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.192 0.19 0.224
Expression system: Escherichia coli

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Citations

1 review citation

Lysine-Targeted Inhibitors and Chemoproteomic Probes.
Cuesta et al. (2019)
12 other articles