Function and Biology Details
Reaction catalysed:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- HEAT, type 2
- Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
- Metallo-dependent phosphatase-like
- EF-hand domain
- EF-hand domain pair
- Calcineurin-like phosphoesterase domain, ApaH type
- Serine/Threonine protein phosphatase PP2A-like
- EF-Hand 1, calcium-binding site
4 more domains
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-151660 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Molecule details ›
Chains: A, D
Length: 584 amino acids
Theoretical weight: 64.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: HEAT repeat
Structure domains: Leucine-rich Repeat Variant
Length: 584 amino acids
Theoretical weight: 64.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P30153 (Residues: 6-589; Coverage: 99%)
Sequence domains: HEAT repeat
Structure domains: Leucine-rich Repeat Variant
Cell division control protein 6 homolog; Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta
Molecule details ›
Chains: B, E
Length: 413 amino acids
Theoretical weight: 47.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains:
Structure domains:
Length: 413 amino acids
Theoretical weight: 47.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: Q9Y5P8 (Residues: 120-490; Coverage: 65%)
- Canonical: Q99741 (Residues: 70-90; Coverage: 4%)
Sequence domains:
Structure domains:
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Molecule details ›
Chains: C, F
Length: 311 amino acids
Theoretical weight: 35.78 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains: Calcineurin-like phosphoesterase
Structure domains: Purple Acid Phosphatase; chain A, domain 2
Length: 311 amino acids
Theoretical weight: 35.78 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical: P67775 (Residues: 1-309; Coverage: 100%)
Sequence domains: Calcineurin-like phosphoesterase
Structure domains: Purple Acid Phosphatase; chain A, domain 2
