› 4iwp

X-ray diffraction
3.06Å resolution

Crystal structure and mechanism of activation of TBK1

Released:
DOI: 10.2210/pdb4iwp/pdb
PDB entry 4iwp coloured by chain, front view.
PDB entry 4iwp coloured by chain, side view.
PDB entry 4iwp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure and mechanism of activation of TANK-binding kinase 1.
Larabi A, Devos JM, Ng SL, Nanao MH, Round A, Maniatis T, Panne D
Cell Rep 3 734-46 (2013)
PMID: 23453971

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193743 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase TBK1 Chain: A
Molecule details ›
Chain: A
Length: 659 amino acids
Theoretical weight: 75.87 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9UHD2 (Residues: 2-657; Coverage: 90%)
Gene names: NAK, TBK1
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand BX7 1 x BX7
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P3221
Unit cell:
a: 135.41Å b: 135.41Å c: 86.36Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.283 0.28 0.335
Expression system: Spodoptera frugiperda

Quick links

Citations

26 review citations

The IκB kinase complex in NF-κB regulation and beyond.
Hinz et al. (2014)
25 more

1 mention without citation

Frustration analysis of TBK1 missense mutations reported in ALS/FTD and cancer patients.
Khatoon et al. (2022)