› 4mpm

X-ray diffraction
1.74Å resolution

Wild-type human neuroglobin

Released:
DOI: 10.2210/pdb4mpm/pdb
PDB entry 4mpm coloured by chain, front view.
PDB entry 4mpm coloured by chain, side view.
PDB entry 4mpm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structure of wild-type human brain neuroglobin reveals flexibility of the disulfide bond that regulates oxygen affinity.
Guimarães BG, Hamdane D, Lechauve C, Marden MC, Golinelli-Pimpaneau B
Acta Crystallogr D Biol Crystallogr 70 1005-14 (2014)
PMID: 24699645

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192481 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neuroglobin Chains: A, B
Molecule details ›
Chains: A, B
Length: 151 amino acids
Theoretical weight: 16.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9NPG2 (Residues: 1-151; Coverage: 100%)
Gene name: NGB
Sequence domains: Globin
Structure domains: Globins

Ligands and Environments

1 bound ligand:
Ligand HEM 2 x HEM
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: P21212
Unit cell:
a: 139.15Å b: 48.49Å c: 39.28Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.184 0.181 0.229
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

6 review citations

Neuroglobin: From structure to function in health and disease.
Ascenzi et al. (2016)
5 more

12 mentions without citation

Neuroglobin and neuroprotection: the role of natural and synthetic compounds in neuroglobin pharmacological induction.
Ciccone et al. (2021)
11 more