› 4qb0

X-ray diffraction
1.75Å resolution

The crystal structure of the C-terminal domain of Ebola (Zaire) nucleoprotein

Released:
DOI: 10.2210/pdb4qb0/pdb
PDB entry 4qb0 coloured by chain, front view.
PDB entry 4qb0 coloured by chain, side view.
PDB entry 4qb0 coloured by chain, top view.
Source organism: Ebola virus - Mayinga, Zaire, 1976
Primary publication:
The structure of the C-terminal domain of the Zaire ebolavirus nucleoprotein.
Dziubańska PJ, Derewenda U, Ellena JF, Engel DA, Derewenda ZS
Acta Crystallogr D Biol Crystallogr 70 2420-9 (2014)
PMID: 25195755

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148340 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nucleoprotein Chain: A
Molecule details ›
Chain: A
Length: 103 amino acids
Theoretical weight: 12.34 KDa
Source organism: Ebola virus - Mayinga, Zaire, 1976
Expression system: Escherichia coli
UniProt:
  • Canonical: P18272 (Residues: 641-739; Coverage: 13%)
Gene name: NP

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: P212121
Unit cell:
a: 36.599Å b: 49.169Å c: 53.806Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.185 0.183 0.225
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Filovirus proteins for antiviral drug discovery: Structure/function bases of the replication cycle.
Martin et al. (2017)
3 more

10 mentions without citation

Structure and assembly of the Ebola virus nucleocapsid.
Wan et al. (2017)
9 more