› 4wlf

X-ray diffraction
2.2Å resolution

Crystal structure of L-malate bound MDH2

Released:
DOI: 10.2210/pdb4wlf/pdb
PDB entry 4wlf coloured by chain, front view.
PDB entry 4wlf coloured by chain, side view.
PDB entry 4wlf coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Eo YM, Han BG, Ahn HC

Function and Biology Details

Reaction catalysed: 
(S)-malate + NAD(+) = oxaloacetate + NADH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-544597 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Malate dehydrogenase, mitochondrial Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 340 amino acids
Theoretical weight: 35.86 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P40926 (Residues: 20-338; Coverage: 94%)
Gene name: MDH2
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand LMR 4 x LMR
Ligand PO4 4 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 7A (6B, 6C1)
Spacegroup: P212121
Unit cell:
a: 60.246Å b: 152.183Å c: 155.034Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.228 0.227 0.247
Expression system: Escherichia coli

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