Function and Biology Details
Reactions catalysed:
5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH
5,10-methenyltetrahydrofolate + H(2)O = 10-formyltetrahydrofolate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Tetrahydrofolate dehydrogenase/cyclohydrolase
- Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
- Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site
- NAD(P)-binding domain superfamily
- Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
- Aminoacid dehydrogenase-like, N-terminal domain superfamily
- Regulatory factor, effector binding domain superfamily
Structure analysis Details
Assembly composition:
homo dimer (preferred)
Assembly name:
Bifunctional protein FolD (preferred)
PDBe Complex ID:
PDB-CPX-111939 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bifunctional protein FolD
Molecule details ›
Chains: A, B
Length: 303 amino acids
Theoretical weight: 32.15 KDa
Source organism: Acinetobacter baumannii ATCC 19606 = CIP 70.34 = JCM 6841
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains:
Length: 303 amino acids
Theoretical weight: 32.15 KDa
Source organism: Acinetobacter baumannii ATCC 19606 = CIP 70.34 = JCM 6841
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
D0CBC8 (Residues: 1-282; Coverage: 100%)
Sequence domains:
- Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
- Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
