› 4djk

X-ray diffraction
3.1Å resolution

Structure of glutamate-GABA antiporter GadC

Released:
DOI: 10.2210/pdb4djk/pdb
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Source organism: Escherichia coli K-12
Primary publication:
Structure and mechanism of a glutamate-GABA antiporter.
Ma D, Lu P, Yan C, Fan C, Yin P, Wang J, Shi Y
Nature 483 632-6 (2012)
PMID: 22407317

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-159057 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate/gamma-aminobutyrate antiporter Chains: A, B
Molecule details ›
Chains: A, B
Length: 511 amino acids
Theoretical weight: 55.11 KDa
Source organism: Escherichia coli K-12
Expression system: Escherichia coli
UniProt:
  • Canonical: P63235 (Residues: 1-511; Coverage: 100%)
Gene names: JW1487, acsA, b1492, gadC, xasA
Sequence domains: Amino acid permease

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P212121
Unit cell:
a: 71.962Å b: 106.408Å c: 185.982Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.285 0.282 0.325
Expression system: Escherichia coli

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Citations

24 review citations

The SLC3 and SLC7 families of amino acid transporters.
Fotiadis et al. (2013)
23 more

7 mentions without citation

Insights into the Structure, Function, and Ligand Discovery of the Large Neutral Amino Acid Transporter 1, LAT1.
Singh et al. (2018)
6 more

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