› 4ivh

X-ray diffraction
1.77Å resolution

Crystal structure of QKLVFFAED nonapeptide segment from amyloid beta incorporated into a macrocyclic beta-sheet template

Released:
DOI: 10.2210/pdb4ivh/pdb
PDB entry 4ivh coloured by chain, front view.
PDB entry 4ivh coloured by chain, side view.
PDB entry 4ivh coloured by chain, top view.
Source organism: synthetic construct
Primary publication:
Structures of beta-Amyloid Peptide Oligomers
Pham JD, Chim N, Goulding CW, Nowick JS
J. Am. Chem. Soc. (2013)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-164592 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
cyclo[Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-(delta-linked-Orn)-Hao-Lys-Hao-(p-bromoPhe)-Thr-(delta-linked-Orn)] Chain: A
Molecule details ›
Chain: A
Length: 16 amino acids
Theoretical weight: 2.25 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand TBU 1 x TBU
Ligand NA 1 x NA
1 modified residue:
Ligand ORN 2 x ORN

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: P622
Unit cell:
a: 45.085Å b: 45.085Å c: 29.247Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.228 0.224 0.271
Expression system: Not provided

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