› 4mvf

X-ray diffraction
2Å resolution

Crystal Structure of Plasmodium falciparum CDPK2 complexed with inhibitor staurosporine

Released:
DOI: 10.2210/pdb4mvf/pdb
PDB entry 4mvf coloured by chain, front view.
PDB entry 4mvf coloured by chain, side view.
PDB entry 4mvf coloured by chain, top view.
Source organism: Plasmodium falciparum K1
Entry authors: Lauciello L, Pernot L, Scapozza L, Perozzo R

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127547 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcium-dependent protein kinase 2 Chain: A
Molecule details ›
Chain: A
Length: 506 amino acids
Theoretical weight: 58.13 KDa
Source organism: Plasmodium falciparum K1
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: O15865 (Residues: 30-511; Coverage: 94%)
Gene names: CDPK2, CPK2
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand STU 1 x STU
Ligand CA 3 x CA
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P212121
Unit cell:
a: 59.15Å b: 92.25Å c: 97.78Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.195 0.193 0.23
Expression system: Escherichia coli BL21

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