Function and Biology

Crystal structure of the BAR-PH domain of ACAP1

Source organism: Homo sapiens
Biochemical function: GTPase activator activity
Biological process: not assigned
Cellular component: cytoplasm

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF00169
The deposited structure of PDB entry 4nsw contains 2 copies of Pfam domain PF00169 (PH domain) in Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1. Showing 1 copy in chain A.

PF16746
Domain description: BAR domain of APPL family
Occurring in:
  1. Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1
The deposited structure of PDB entry 4nsw contains 2 copies of Pfam domain PF16746 (BAR domain of APPL family) in Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001849
Domain description: Pleckstrin homology domain
Occurring in:
  1. Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1
IPR027267
Domain description: AH/BAR domain superfamily
Occurring in:
  1. Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1
IPR011993
Domain description: PH-like domain superfamily
Occurring in:
  1. Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1
IPR045258
Domain description: ArfGAP ACAP1/2/3-like
Occurring in:
  1. Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1
IPR004148

Structure domains

CATH CATH domains
2.30.29.30
Class: Mainly Beta
Architecture: Roll
Topology: PH-domain like
Homology: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Occurring in:
  1. Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1
The deposited structure of PDB entry 4nsw contains 2 copies of CATH domain 2.30.29.30 (PH-domain like) in Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1. Showing 1 copy in chain A.
1.20.1270.60
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Substrate Binding Domain Of Dnak; Chain:A; Domain 2
Homology: Arfaptin homology (AH) domain/BAR domain
Occurring in:
  1. Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1
The deposited structure of PDB entry 4nsw contains 2 copies of CATH domain 1.20.1270.60 (Substrate Binding Domain Of Dnak; Chain:A; Domain 2) in Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1. Showing 1 copy in chain A.