› 4usf

X-ray diffraction
1.75Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190546 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
STE20-like serine/threonine-protein kinase Chains: A, B
Molecule details ›
Chains: A, B
Length: 304 amino acids
Theoretical weight: 34.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9H2G2 (Residues: 19-320; Coverage: 25%)
Gene names: KIAA0204, SLK, STK2
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 6UI 2 x 6UI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Unit cell:
a: 49.94Å b: 75.3Å c: 189.57Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.198 0.197 0.228
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

29 review citations

Drug repurposing: progress, challenges and recommendations.
Pushpakom et al. (2019)
28 more