› 4z2g

X-ray diffraction
2.6Å resolution

Function and Biology Details

Reaction catalysed: 
Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-145920 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Chitinase B Chain: A
Molecule details ›
Chain: A
Length: 503 amino acids
Theoretical weight: 55.93 KDa
Source organism: Serratia marcescens
Expression system: Escherichia coli DH5[alpha]
UniProt:
  • Canonical: P11797 (Residues: 2-499; Coverage: 100%)
Gene name: chiB
Sequence domains: Glycosyl hydrolases family 18
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand M6V 2 x M6V
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-17A
Spacegroup: P43212
Unit cell:
a: 96.98Å b: 96.98Å c: 193.84Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.233 0.229 0.294
Expression system: Escherichia coli DH5[alpha]

Quick links

Citations

1 review citation

The chemistry and biology of guanidine natural products.
Berlinck et al. (2017)
1 other article

1 mention without citation

Scaffold repositioning of spiro-acridine derivatives as fungi chitinase inhibitor by target fishing and in vitro studies.
de Oliveira Viana et al. (2023)