› 4zl4

X-ray diffraction
2.37Å resolution

Plasmepsin V from Plasmodium vivax bound to a transition state mimetic (WEHI-842)

Released:
DOI: 10.2210/pdb4zl4/pdb
PDB entry 4zl4 coloured by chain, front view.
PDB entry 4zl4 coloured by chain, side view.
PDB entry 4zl4 coloured by chain, top view.
Source organism: Plasmodium vivax
Primary publication:
Structural basis for plasmepsin V inhibition that blocks export of malaria proteins to human erythrocytes.
Hodder AN, Sleebs BE, Czabotar PE, Gazdik M, Xu Y, O'Neill MT, Lopaticki S, Nebl T, Triglia T, Smith BJ, Lowes K, Boddey JA, Cowman AF
Nat Struct Mol Biol 22 590-6 (2015)
PMID: 26214367

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-107661 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Plasmepsin V Chains: A, B
Molecule details ›
Chains: A, B
Length: 444 amino acids
Theoretical weight: 50.58 KDa
Source organism: Plasmodium vivax
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: A5K302 (Residues: 35-476; Coverage: 88%)
Gene names: PMV, PVX_116695
Sequence domains:

Ligands and Environments

4 bound ligands:
Ligand 4PK 2 x 4PK
Ligand SO4 7 x SO4
Ligand EDO 6 x EDO
Ligand 4PF 1 x 4PF
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: C2
Unit cell:
a: 91.994Å b: 203.089Å c: 82.165Å
α: 90° β: 121.07° γ: 90°
R-values:
R R work R free
0.181 0.179 0.224
Expression system: Spodoptera frugiperda

Quick links

Citations

14 review citations

Drugs in Development for Malaria.
Ashley et al. (2018)
13 more

13 mentions without citation

Malaria parasite plasmepsins: More than just plain old degradative pepsins.
Nasamu et al. (2020)
12 more