Function and Biology Details
Reaction catalysed:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-143257 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
WD repeat-containing protein 48
Molecule details ›
Chain: A
Length: 598 amino acids
Theoretical weight: 67.15 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains:
Length: 598 amino acids
Theoretical weight: 67.15 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
Q8TAF3 (Residues: 2-580; Coverage: 86%)
Sequence domains:
Ubiquitin carboxyl-terminal hydrolase 46
Molecule details ›
Chain: B
Length: 358 amino acids
Theoretical weight: 41.96 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt: Gene name: USP46
Sequence domains: Ubiquitin carboxyl-terminal hydrolase
Structure domains: Cysteine proteinases
Length: 358 amino acids
Theoretical weight: 41.96 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt: Gene name: USP46
Sequence domains: Ubiquitin carboxyl-terminal hydrolase
Structure domains: Cysteine proteinases
Ubiquitin
Molecule details ›
Chain: D
Length: 96 amino acids
Theoretical weight: 10.75 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains: Ubiquitin family
Length: 96 amino acids
Theoretical weight: 10.75 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical: P0CG47 (Residues: 153-228; Coverage: 33%)
Sequence domains: Ubiquitin family
