› 5iyy

X-ray diffraction
1.6Å resolution

X-ray structure of neuropilin-1 b1 domain complexed with Arg-4 ligand.

Released:
DOI: 10.2210/pdb5iyy/pdb
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Source organism: Homo sapiens
Primary publication:
Architecture and hydration of the arginine-binding site of neuropilin-1.
Mota F, Fotinou C, Rana RR, Chan AWE, Yelland T, Arooz MT, O'Leary AP, Hutton J, Frankel P, Zachary I, Selwood D, Djordjevic S
OpenAccess logo FEBS J 285 1290-1304 (2018)
PMID: 29430837

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127136 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neuropilin-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 158 amino acids
Theoretical weight: 17.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O14786 (Residues: 273-427; Coverage: 17%)
Gene names: NRP, NRP1, VEGF165R
Sequence domains: F5/8 type C domain
Structure domains: Galactose-binding domain-like

Ligands and Environments

1 bound ligand:
Ligand R40 2 x R40
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P21
Unit cell:
a: 41.525Å b: 88.945Å c: 41.7Å
α: 90° β: 91.61° γ: 90°
R-values:
R R work R free
0.148 0.146 0.187
Expression system: Escherichia coli BL21(DE3)

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Citations

5 review citations

Molecular Pharmacology of VEGF-A Isoforms: Binding and Signalling at VEGFR2.
Peach et al. (2018)
4 more

2 mentions without citation

Architecture and hydration of the arginine-binding site of neuropilin-1.
Mota et al. (2018)
1 more

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