Function and Biology

Crystal structure of a mycobacterial protein

EC 6.2.1.20: Long-chain-fatty-acid--[acyl-carrier-protein] ligase

Reaction catalysed:
ATP + a long-chain fatty acid + an [acyl-carrier-protein] = AMP + diphosphate + a long-chain acyl-[acyl-carrier-protein]
Systematic name:
Long-chain-fatty-acid:[acyl-carrier protein] ligase (AMP-forming)
Alternative Name(s):
  • Acyl-ACP synthetase
  • Acyl-[acyl carrier protein] synthetase
  • Acyl-[acyl-carrier-protein] synthetase
  • Acyl-acyl carrier protein synthetase
  • Long-chain-fatty-acid:[acyl-carrier-protein] ligase (AMP-forming)
  • Stearoyl-ACP synthetase

Sequence families

Pfam Protein families (Pfam)
PF00240
Domain description: Ubiquitin family
Occurring in:
  1. Ubiquitin-like protein SMT3
The deposited structure of PDB entry 5d6j contains 1 copy of Pfam domain PF00240 (Ubiquitin family) in Ubiquitin-like protein SMT3. Showing 1 copy in chain B.

PF00501
Domain description: AMP-binding enzyme
Occurring in:
  1. Long-chain-fatty-acid--AMP ligase FadD32
The deposited structure of PDB entry 5d6j contains 1 copy of Pfam domain PF00501 (AMP-binding enzyme) in Long-chain-fatty-acid--AMP ligase FadD32. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000626
Domain description: Ubiquitin-like domain
Occurring in:
  1. Ubiquitin-like protein SMT3
IPR022617
Domain description: Rad60/SUMO-like domain
Occurring in:
  1. Ubiquitin-like protein SMT3
IPR029071
Domain description: Ubiquitin-like domain superfamily
Occurring in:
  1. Ubiquitin-like protein SMT3
IPR045851
Domain description: AMP-binding enzyme, C-terminal domain superfamily
Occurring in:
  1. Long-chain-fatty-acid--AMP ligase FadD32
IPR040097
Domain description: Fatty acyl-AMP ligase /fatty acyl-CoA ligase
Occurring in:
  1. Long-chain-fatty-acid--AMP ligase FadD32
IPR000873
Domain description: AMP-dependent synthetase/ligase domain
Occurring in:
  1. Long-chain-fatty-acid--AMP ligase FadD32
IPR047968
Domain description: Long-chain-fatty-acid--AMP ligase FadD32
Occurring in:
  1. Long-chain-fatty-acid--AMP ligase FadD32
IPR042099
Domain description: ANL, N-terminal domain
Occurring in:
  1. Long-chain-fatty-acid--AMP ligase FadD32

Structure domain

CATH CATH domain
3.10.20.90
Class: Alpha Beta
Architecture: Roll
Topology: Ubiquitin-like (UB roll)
Homology: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
Occurring in:
  1. Ubiquitin-like protein SMT3
The deposited structure of PDB entry 5d6j contains 1 copy of CATH domain 3.10.20.90 (Ubiquitin-like (UB roll)) in Ubiquitin-like protein SMT3. Showing 1 copy in chain B.