› 5hvd

X-ray diffraction
2.6Å resolution

Full length Open-form Sodium Channel NavMs I218C

Released:
DOI: 10.2210/pdb5hvd/pdb
PDB entry 5hvd coloured by chain, front view.
PDB entry 5hvd coloured by chain, side view.
PDB entry 5hvd coloured by chain, top view.
Source organism: Magnetococcus marinus MC-1
Primary publication:
The complete structure of an activated open sodium channel.
Sula A, Booker J, Ng LC, Naylor CE, DeCaen PG, Wallace BA
OpenAccess logo Nat Commun 8 14205 (2017)
PMID: 28205548

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-106115 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ion transport domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 277 amino acids
Theoretical weight: 31.21 KDa
Source organism: Magnetococcus marinus MC-1
Expression system: Escherichia coli
UniProt:
  • Canonical: A0L5S6 (Residues: 1-274; Coverage: 100%)
Gene name: Mmc1_0798
Sequence domains:

Ligands and Environments

4 bound ligands:
Ligand NA 3 x NA
Ligand 2CV 1 x 2CV
Ligand 12P 1 x 12P
Ligand MES 1 x MES
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 2
Spacegroup: I422
Unit cell:
a: 109.58Å b: 109.58Å c: 209.71Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.194 0.192 0.214
Expression system: Escherichia coli

Quick links

Citations

20 review citations

Challenges and Opportunities for Therapeutics Targeting the Voltage-Gated Sodium Channel Isoform NaV1.7.
Mulcahy et al. (2019)
19 more

7 mentions without citation

Structural basis of G-quadruplex unfolding by the DEAH/RHA helicase DHX36.
Chen et al. (2018)
6 more