› 5mpm

X-ray diffraction
3.3Å resolution

SERCA2a from pig heart

Released:
DOI: 10.2210/pdb5mpm/pdb
Model geometry
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PDB entry 5mpm coloured by chain, front view.
PDB entry 5mpm coloured by chain, side view.
PDB entry 5mpm coloured by chain, top view.
Source organism: Sus scrofa
Primary publication:
Structures of the heart specific SERCA2a Ca2+-ATPase.
Sitsel A, De Raeymaecker J, Drachmann ND, Derua R, Smaardijk S, Andersen JL, Vandecaetsbeek I, Chen J, De Maeyer M, Waelkens E, Olesen C, Vangheluwe P, Nissen P
EMBO J 38 (2019)
PMID: 30777856

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145885 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 Chain: A
Molecule details ›
Chain: A
Length: 997 amino acids
Theoretical weight: 109.84 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: P11607 (Residues: 1-993; Coverage: 95%)
  • Best match: P11607-2 (Residues: 1-997)
Gene name: ATP2A2
Sequence domains:
Structure domains:

Ligands and Environments

4 bound ligands:
Ligand MGF 1 x MGF
Ligand CZA 1 x CZA
Ligand MG 2 x MG
Ligand K 1 x K
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21
Unit cell:
a: 53.349Å b: 253.287Å c: 64.981Å
α: 90° β: 100.86° γ: 90°
R-values:
R R work R free
0.208 0.204 0.258

Quick links

Citations

7 review citations

SERCA2a: a key protein in the Ca2+ cycle of the heart failure.
Zhihao et al. (2020)
6 more

5 mentions without citation

Linking Biochemical and Structural States of SERCA: Achievements, Challenges, and New Opportunities.
Aguayo-Ortiz et al. (2020)
4 more

PDB-REDO

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