› 5oxl

X-ray diffraction
2.66Å resolution

PepTSt in complex with dipeptide Ala-Leu

Released:
DOI: 10.2210/pdb5oxl/pdb
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Source organism: Streptococcus thermophilus LMG 18311
Primary publication:
Multispecific Substrate Recognition in a Proton-Dependent Oligopeptide Transporter.
Martinez Molledo M, Quistgaard EM, Flayhan A, Pieprzyk J, Löw C
OpenAccess logo Structure 26 467-476.e4 (2018)
PMID: 29429879

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-177587 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Major facilitator superfamily (MFS) profile domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 490 amino acids
Theoretical weight: 53.65 KDa
Source organism: Streptococcus thermophilus LMG 18311
Expression system: Escherichia coli
UniProt:
  • Canonical: Q5M4H8 (Residues: 1-483; Coverage: 100%)
Gene names: dtpT, stu0970
Sequence domains: POT family

Ligands and Environments

7 bound ligands:
Ligand PO4 2 x PO4
Ligand EPE 1 x EPE
Ligand 1PE 2 x 1PE
Ligand 78N 9 x 78N
Ligand 78M 1 x 78M
Ligand ALA 1 x ALA
Ligand LEU 1 x LEU
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ESRF BEAMLINE MASSIF-1
Spacegroup: C2221
Unit cell:
a: 102.3Å b: 110.6Å c: 108.5Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.224 0.224 0.233
Expression system: Escherichia coli

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Citations

3 review citations

Systemic tryptophan homeostasis.
Klaessens et al. (2022)
2 more

2 mentions without citation

Recent advances in understanding prodrug transport through the SLC15 family of proton-coupled transporters.
Minhas et al. (2020)
1 more

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