› 5sb0

X-ray diffraction
1.97Å resolution

DDR1, N-[[2-(2-pyridin-3-yloxyethyl)cyclohexyl]methyl]-3-(trifluoromethoxy)benzamide, 1.970A, P212121, Rfree=25.6%

Released:
DOI: 10.2210/pdb5sb0/pdb
PDB entry 5sb0 coloured by chain, front view.
PDB entry 5sb0 coloured by chain, side view.
PDB entry 5sb0 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Stihle M, Richter H, Benz J, Hochstrasser R, Rudolph MG

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170636 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Epithelial discoidin domain-containing receptor 1 Chain: A
Molecule details ›
Chain: A
Length: 321 amino acids
Theoretical weight: 36.5 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q08345 (Residues: 593-913; Coverage: 35%)
Gene names: CAK, DDR1, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE
Sequence domains: Protein tyrosine and serine/threonine kinase

Ligands and Environments

3 bound ligands:
Ligand IOD 1 x IOD
Ligand 1IZ 1 x 1IZ
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P212121
Unit cell:
a: 62.056Å b: 76.661Å c: 77.783Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.21 0.208 0.256
Expression system: Spodoptera frugiperda

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