› 5us3

Solution NMR

Heterogeneous-backbone Foldamer Mimic of the Sp1-3 Zinc Finger

Released:
DOI: 10.2210/pdb5us3/pdb
PDB entry 5us3 coloured by chain, ensemble of 9 models, front view.
PDB entry 5us3 coloured by chain, ensemble of 9 models, side view.
PDB entry 5us3 coloured by chain, ensemble of 9 models, top view.
Source organism: Homo sapiens
Primary publication:
Heterogeneous-Backbone Foldamer Mimics of Zinc Finger Tertiary Structure.
George KL, Horne WS
J Am Chem Soc 139 7931-7938 (2017)
PMID: 28509549

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-166180 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Heterogeneous-Backbone Variant of the Sp1-3 Zinc Finger: N-Me-Ala3, N-Me-Arg10, beta-3-Asp15, beta-3-Lys19, beta3-Lys22, beta-3-Gln25 Chain: A
Molecule details ›
Chain: A
Length: 29 amino acids
Theoretical weight: 3.48 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
6 modified residues:
Ligand MAA 1 x MAA
Ligand MMO 1 x MMO
Ligand NLE 1 x NLE
Ligand B3D 1 x B3D
Ligand B3K 2 x B3K
Ligand B3Q 1 x B3Q

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 51%
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

4 review citations

Metal-Binding Foldamers.
Rao et al. (2021)
3 more

5 mentions without citation

Proteomimetics as protein-inspired scaffolds with defined tertiary folding patterns.
Horne et al. (2020)
4 more