› 5y5t

X-ray diffraction
1.8Å resolution

Crystal structures of spleen tyrosine kinase in complex with a novel inhibitor

Released:
DOI: 10.2210/pdb5y5t/pdb
PDB entry 5y5t coloured by chain, front view.
PDB entry 5y5t coloured by chain, side view.
PDB entry 5y5t coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal Structures of Spleen Tyrosine Kinase in Complex with Two Novel 4-Aminopyrido[4,3-d] Pyrimidine Derivative Inhibitors.
Lee SJ, Choi JS, Bong SM, Hwang HJ, Lee J, Song HJ, Lee J, Kim JH, Koh JS, Lee BI
OpenAccess logo Mol Cells 41 545-552 (2018)
PMID: 29890824

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155056 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase SYK Chain: A
Molecule details ›
Chain: A
Length: 293 amino acids
Theoretical weight: 34.22 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P43405 (Residues: 356-635; Coverage: 44%)
Gene name: SYK
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 8OR 1 x 8OR
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 5C (4A)
Spacegroup: P21
Unit cell:
a: 40.246Å b: 84.979Å c: 42.142Å
α: 90° β: 99.59° γ: 90°
R-values:
R R work R free
0.196 0.194 0.234
Expression system: Spodoptera frugiperda

Quick links

Citations

1 mention without citation

Crystal Structures of Spleen Tyrosine Kinase in Complex with Two Novel 4-Aminopyrido[4,3-d] Pyrimidine Derivative Inhibitors.
Lee et al. (2018)