› 6fwn

Solution NMR

Structure and dynamics of the platelet integrin-binding C4 domain of von Willebrand factor

Released:
DOI: 10.2210/pdb6fwn/pdb
PDB entry 6fwn coloured by chain, ensemble of 20 models, front view.
PDB entry 6fwn coloured by chain, ensemble of 20 models, side view.
PDB entry 6fwn coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structure and dynamics of the platelet integrin-binding C4 domain of von Willebrand factor.
Xu ER, von Bülow S, Chen PC, Lenting PJ, Kolšek K, Aponte-Santamaría C, Simon B, Foot J, Obser T, Schneppenheim R, Gräter F, Denis CV, Wilmanns M, Hennig J
Blood 133 366-376 (2019)
PMID: 30305279

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137563 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
von Willebrand factor Chain: A
Molecule details ›
Chain: A
Length: 85 amino acids
Theoretical weight: 9.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P04275 (Residues: 2497-2577; Coverage: 3%)
Gene names: F8VWF, VWF

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 87%
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

Imaging Platelet Processes and Function-Current and Emerging Approaches for Imaging in vitro and in vivo.
Montague et al. (2020)
2 more

3 mentions without citation

Structure and dynamics of the platelet integrin-binding C4 domain of von Willebrand factor.
Xu et al. (2019)
2 more