› 6mjx

X-ray diffraction
2.6Å resolution

Function and Biology Details

Reaction catalysed: 
(1a) ATP + GTP = pppG-P(2'-5')A + diphosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185433 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cyclic GMP-AMP synthase Chain: A
Molecule details ›
Chain: A
Length: 372 amino acids
Theoretical weight: 43.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8N884 (Residues: 152-522; Coverage: 71%)
Gene names: C6orf150, CGAS, MB21D1
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand 1SY 1 x 1SY
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P21212
Unit cell:
a: 128.006Å b: 50.424Å c: 59.969Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.226 0.221 0.265
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

52 review citations

The cGAS-STING pathway as a therapeutic target in inflammatory diseases.
Decout et al. (2021)
51 more

2 mentions without citation

Molecular and Structural Basis of DNA Sensors in Antiviral Innate Immunity.
Zahid et al. (2020)
1 more