› 6mx3

X-ray diffraction
1.36Å resolution

Crystal structure of human STING (G230A, H232R, R293Q) in complex with Compound 1

Released:
DOI: 10.2210/pdb6mx3/pdb
Model geometry
Fit model/data
PDB entry 6mx3 coloured by chain, front view.
PDB entry 6mx3 coloured by chain, side view.
PDB entry 6mx3 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Discovery of a Novel cGAMP Competitive Ligand of the Inactive Form of STING.
Siu T, Altman MD, Baltus GA, Childers M, Ellis JM, Gunaydin H, Hatch H, Ho T, Jewell J, Lacey BM, Lesburg CA, Pan BS, Sauvagnat B, Schroeder GK, Xu S
ACS Med Chem Lett 10 92-97 (2019)
PMID: 30655953

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183240 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Stimulator of interferon genes protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 188 amino acids
Theoretical weight: 21.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q86WV6 (Residues: 155-341; Coverage: 49%)
Gene names: ERIS, MITA, STING, STING1, TMEM173
Sequence domains: Transmembrane protein 173
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand K5P 2 x K5P
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 17-ID
Spacegroup: C2221
Unit cell:
a: 70.2Å b: 77.71Å c: 125.41Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.188 0.188 0.202
Expression system: Escherichia coli

Quick links

Citations

36 review citations

The cGAS-STING pathway as a therapeutic target in inflammatory diseases.
Decout et al. (2021)
35 more

3 mentions without citation

Inhibitory targeting cGAS-STING-TBK1 axis: Emerging strategies for autoimmune diseases therapy.
Zhang et al. (2022)
2 more