› 6sja

X-ray diffraction
1.5Å resolution

Structure of HPV16 E6 oncoprotein in complex with IRF3 LxxLL motif

Released:
DOI: 10.2210/pdb6sja/pdb
PDB entry 6sja coloured by chain, front view.
PDB entry 6sja coloured by chain, side view.
PDB entry 6sja coloured by chain, top view.
Source organisms:
Entry authors: Suarez IP, Cousido-Siah A, Bonhoure A, Mitschler A, Podjarny A, Trave G

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136588 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Interferon regulatory factor 3; Maltose/maltodextrin-binding periplasmic protein Chain: A
Molecule details ›
Chain: A
Length: 383 amino acids
Theoretical weight: 41.73 KDa
Source organisms: Expression system: Escherichia coli
UniProt:
  • Canonical: P0AEX9 (Residues: 27-387; Coverage: 98%)
  • Canonical: Q14653 (Residues: 137-148; Coverage: 3%)
Gene names: IRF3, JW3994, b4034, malE
Sequence domains: Bacterial extracellular solute-binding protein
Protein E6 Chain: B
Molecule details ›
Chain: B
Length: 153 amino acids
Theoretical weight: 18.44 KDa
Source organism: Human papillomavirus 16
Expression system: Escherichia coli
UniProt:
  • Canonical: P03126 (Residues: 7-158; Coverage: 96%)
Gene name: E6
Sequence domains: Early Protein (E6)

Ligands and Environments

Carbohydrate polymer : NEW Components: GLC
Carbohydrate polymer
1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P21212
Unit cell:
a: 97.659Å b: 132.87Å c: 43.025Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.161 0.159 0.19
Expression system: Escherichia coli

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