› 6b5q

X-ray diffraction
2.16Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-166449 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
DCN1-like protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 225 amino acids
Theoretical weight: 26.25 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96GG9 (Residues: 58-259; Coverage: 78%)
Gene names: DCN1, DCUN1D1, DCUN1L1, RP42, SCCRO
Sequence domains: Cullin binding
Structure domains: EF-hand
Peptidomimetic Inhibitors DI-591 Chains: D, E
Molecule details ›
Chains: D, E
Length: 5 amino acids
Theoretical weight: 725 Da
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand PGE 2 x PGE
2 modified residues:
Ligand CZS 2 x CZS
Ligand MLY 2 x MLY

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: C2221
Unit cell:
a: 88.087Å b: 90.841Å c: 105.01Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.197 0.195 0.241
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

8 review citations

Insights into the post-translational modification and its emerging role in shaping the tumor microenvironment.
Li et al. (2021)
7 more

1 mention without citation

Anticancer drug discovery by targeting cullin neddylation.
Yu et al. (2020)