› 6c9c

X-ray diffraction
2Å resolution

Crystal structure of LpxC from Pseudomonas aeruginosa in complex with racemic ligand PT803

Released:
DOI: 10.2210/pdb6c9c/pdb
PDB entry 6c9c coloured by chain, front view.
PDB entry 6c9c coloured by chain, side view.
PDB entry 6c9c coloured by chain, top view.
Source organism: Pseudomonas aeruginosa UCBPP-PA14
Entry author: Seattle Structural Genomics Center for Infectious Disease (SSGCID)

Function and Biology Details

Reaction catalysed: 
UDP-3-O-((3R)-3-hydroxyacyl)-N-acetyl-alpha-D-glucosamine + H(2)O = UDP-3-O-((3R)-3-hydroxyacyl)-alpha-D-glucosamine + acetate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169792 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
UDP-3-O-acyl-N-acetylglucosamine deacetylase Chain: A
Molecule details ›
Chain: A
Length: 304 amino acids
Theoretical weight: 33.56 KDa
Source organism: Pseudomonas aeruginosa UCBPP-PA14
Expression system: Escherichia coli
UniProt:
  • Canonical: Q02H34 (Residues: 1-303; Coverage: 100%)
Gene names: PA14_57260, lpxC
Sequence domains: UDP-3-O-acyl N-acetylglycosamine deacetylase
Structure domains:

Ligands and Environments

4 bound ligands:
Ligand EU1 1 x EU1
Ligand F64 1 x F64
Ligand ZN 1 x ZN
Ligand EDO 5 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P21
Unit cell:
a: 35.66Å b: 79.34Å c: 50.92Å
α: 90° β: 92.01° γ: 90°
R-values:
R R work R free
0.168 0.162 0.213
Expression system: Escherichia coli

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