› 6d1p

X-ray diffraction
2.35Å resolution

Apo structure of Bacteroides uniformis beta-glucuronidase 3

Released:
DOI: 10.2210/pdb6d1p/pdb
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PDB entry 6d1p coloured by chain, front view.
PDB entry 6d1p coloured by chain, side view.
PDB entry 6d1p coloured by chain, top view.
Source organism: Bacteroides uniformis str. 3978 T3 ii
Primary publication:
Three structurally and functionally distinct β-glucuronidases from the human gut microbe Bacteroides uniformis.
Pellock SJ, Walton WG, Biernat KA, Torres-Rivera D, Creekmore BC, Xu Y, Liu J, Tripathy A, Stewart LJ, Redinbo MR
J Biol Chem 293 18559-18573 (2018)
PMID: 30301767

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-100554 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glycosyl hydrolases family 2, sugar binding domain protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 814 amino acids
Theoretical weight: 93.19 KDa
Source organism: Bacteroides uniformis str. 3978 T3 ii
Expression system: Escherichia coli
UniProt:
  • Canonical: A0A078SSU5 (Residues: 1-814; Coverage: 100%)
Gene name: M094_3281
Sequence domains:

Ligands and Environments

4 bound ligands:
Ligand NA 5 x NA
Ligand GOL 5 x GOL
Ligand SCN 2 x SCN
Ligand K 4 x K
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: C2
Unit cell:
a: 209.721Å b: 68.209Å c: 167.3Å
α: 90° β: 122.49° γ: 90°
R-values:
R R work R free
0.177 0.176 0.222
Expression system: Escherichia coli

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Citations

5 review citations

The Role of Gut Microbial β-Glucuronidase in Estrogen Reactivation and Breast Cancer.
Sui et al. (2021)
4 more

2 mentions without citation

Three structurally and functionally distinct β-glucuronidases from the human gut microbe Bacteroides uniformis.
Pellock et al. (2018)
1 more

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