Function and Biology Details
Reaction catalysed:
(1a) a [histone H3]-N(6),N(6),N(6)-trimethyl-L-lysine(27) + 2-oxoglutarate + O(2) = a [histone H3]-N(6),N(6)-dimethyl-L-lysine(27) + succinate + formaldehyde + CO(2)
Biochemical function:
- not assigned
Biological process:
- not assigned
Cellular component:
- not assigned
Sequence domains:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
Histone H3.1 and Lysine-specific demethylase 6B (preferred)
PDBe Complex ID:
PDB-CPX-127276 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Lysine-specific demethylase 6B
Molecule details ›
Chain: A
Length: 510 amino acids
Theoretical weight: 58.05 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains:
Length: 510 amino acids
Theoretical weight: 58.05 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical:
O15054 (Residues: 1141-1643; Coverage: 31%)
Sequence domains:
- JmjC domain, hydroxylase
- Lysine-specific demethylase 6/UTY, C-terminal helical domain
- KDM6, GATA-like
Histone H3.1
Molecule details ›
Chain: B
Length: 17 amino acids
Theoretical weight: 1.8 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
Length: 17 amino acids
Theoretical weight: 1.8 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
- Canonical: P68431 (Residues: 18-34; Coverage: 13%)
