› 6g4y

X-ray diffraction
2.65Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-194391 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase kinase kinase 14 Chains: A, B
Molecule details ›
Chains: A, B
Length: 349 amino acids
Theoretical weight: 38.54 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9WUL6 (Residues: 329-675; Coverage: 37%)
Gene names: Map3k14, Nik
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand SO4 4 x SO4
Ligand ELZ 2 x ELZ
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P43
Unit cell:
a: 143.829Å b: 143.829Å c: 45.614Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.198 0.196 0.249
Expression system: Spodoptera frugiperda

Quick links

Citations

6 review citations

Targeting NF-κB-Inducing Kinase (NIK) in Immunity, Inflammation, and Cancer.
Pflug et al. (2020)
5 more

1 mention without citation

Pharmacological inhibition of NF-κB-inducing kinase (NIK) with small molecules for the treatment of human diseases.
Cheng et al. (2021)