› 6hg0

X-ray diffraction
1.3Å resolution

Influenza A Virus N9 Neuraminidase complex with NANA (Tern/Australia).

Released:
DOI: 10.2210/pdb6hg0/pdb
PDB entry 6hg0 coloured by chain, front view.
PDB entry 6hg0 coloured by chain, side view.
PDB entry 6hg0 coloured by chain, top view.
Source organism: Influenza A virus (A/tern/Australia/G70C/1975(H11N9))
Entry authors: Salinger MT, Hobbs JR, Murray JW, Laver WG, Kuhn P, Garman EF

Function and Biology Details

Reaction catalysed: 
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137058 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Neuraminidase Chain: A
Molecule details ›
Chain: A
Length: 388 amino acids
Theoretical weight: 43.72 KDa
Source organism: Influenza A virus (A/tern/Australia/G70C/1975(H11N9))
UniProt:
  • Canonical: P03472 (Residues: 83-470; Coverage: 83%)
Gene name: NA
Sequence domains: Neuraminidase
Structure domains: Neuraminidase

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
5 bound ligands:
Ligand CA 2 x CA
Ligand GOL 4 x GOL
Ligand PO4 1 x PO4
Ligand SIA 2 x SIA
Ligand K 1 x K
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: I432
Unit cell:
a: 181.2Å b: 181.2Å c: 181.2Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.093 0.091 0.12

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