Function and Biology Details
Reaction catalysed:
(R)-mevalonate + CoA + 2 NADP(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH
Biochemical function:
Biological process:
Cellular component:
- not assigned
Sequence domains:
- Hydroxymethylglutaryl-CoA reductase, class I/II
- Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site
- Hydroxymethylglutaryl-CoA reductase, eukaryotic/archaeal type
- Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain superfamily
- Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain superfamily
- Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain superfamily
- AhpD-like
Structure analysis Details
Assemblies composition:
Assembly name:
3-hydroxy-3-methylglutaryl coenzyme A reductase (preferred)
PDBe Complex ID:
PDB-CPX-105200 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
3-hydroxy-3-methylglutaryl coenzyme A reductase
Molecule details ›
Chain: A
Length: 427 amino acids
Theoretical weight: 46.65 KDa
Source organism: Methanothermococcus thermolithotrophicus DSM 2095
Expression system: Escherichia coli BL21
UniProt:
Sequence domains: Hydroxymethylglutaryl-coenzyme A reductase
Structure domains:
Length: 427 amino acids
Theoretical weight: 46.65 KDa
Source organism: Methanothermococcus thermolithotrophicus DSM 2095
Expression system: Escherichia coli BL21
UniProt:
- Canonical:
A0A4V8GZY0 (Residues: 1-407; Coverage: 100%)
Sequence domains: Hydroxymethylglutaryl-coenzyme A reductase
Structure domains:
3-hydroxy-3-methylglutaryl coenzyme A reductase
Molecule details ›
Chains: B, C, D, E, F
Length: 427 amino acids
Theoretical weight: 46.64 KDa
Source organism: Methanothermococcus thermolithotrophicus DSM 2095
Expression system: Escherichia coli BL21
UniProt:
Sequence domains: Hydroxymethylglutaryl-coenzyme A reductase
Structure domains:
Length: 427 amino acids
Theoretical weight: 46.64 KDa
Source organism: Methanothermococcus thermolithotrophicus DSM 2095
Expression system: Escherichia coli BL21
UniProt:
- Canonical: A0A4V8GZY0 (Residues: 1-407; Coverage: 100%)
Sequence domains: Hydroxymethylglutaryl-coenzyme A reductase
Structure domains:
