Function and Biology Details
Reaction catalysed:
Cleaves selectively Arg-|-Xaa and Lys-|-Xaa bonds, including Lys-|-Arg and Arg-|-Ser bonds in (human) kininogen to release bradykinin.
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
monomeric (preferred)
Assembly name:
Plasma kallikrein light chain (preferred)
PDBe Complex ID:
PDB-CPX-137291 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Plasma kallikrein
Molecule details ›
Chain: A
Length: 627 amino acids
Theoretical weight: 70.15 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
Sequence domains:
Length: 627 amino acids
Theoretical weight: 70.15 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
- Canonical:
P03952 (Residues: 20-638; Coverage: 100%)
Sequence domains:
Ligands and Environments
Experiments and Validation Details
X-ray source:
DIAMOND BEAMLINE I03
Spacegroup:
P21212
Expression system: Drosophila melanogaster
