› 6iql

X-ray diffraction
3.5Å resolution

Crystal structure of dopamine receptor D4 bound to the subtype-selective ligand, L745870

Released:
DOI: 10.2210/pdb6iql/pdb
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Source organisms:
Primary publication:
Crystal structure of dopamine receptor D4 bound to the subtype selective ligand, L745870.
Zhou Y, Cao C, He L, Wang X, Zhang XC
OpenAccess logo Elife 8 (2019)
PMID: 31750832

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-142104 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
D(4) dopamine receptor; Soluble cytochrome b562 Chains: A, B
Molecule details ›
Chains: A, B
Length: 396 amino acids
Theoretical weight: 43.57 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P51436 (Residues: 23-219, 304-387; Coverage: 73%)
  • Canonical: P0ABE7 (Residues: 24-127; Coverage: 98%)
Gene names: Drd4, cybC
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand L74 2 x L74
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SPRING-8 BEAMLINE BL41XU
Unit cell:
a: 46.7Å b: 142Å c: 146Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.307 0.306 0.336
Expression system: Spodoptera frugiperda

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Citations

1 review citation

Fentanyl Structure as a Scaffold for Opioid/Non-Opioid Multitarget Analgesics.
Lipiński et al. (2022)
8 other articles

7 mentions without citation

G protein-coupled receptors: structure- and function-based drug discovery.
Yang et al. (2021)
6 more

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