› 6lf7

X-ray diffraction
1.79Å resolution

Crystal structure of the complex of goat lactoperoxidase with hypothiocyanite and hydrogen peroxide at 1.79 A resolution.

Released:
DOI: 10.2210/pdb6lf7/pdb
PDB entry 6lf7 coloured by chain, front view.
PDB entry 6lf7 coloured by chain, side view.
PDB entry 6lf7 coloured by chain, top view.
Source organism: Capra hircus
Entry authors: Viswanathan V, Tyagi TK, Singh RP, Singh AK, Singh A, Bhushan A, Sinha M, Kaur P, Sharma S, Singh TP

Function and Biology Details

Reaction catalysed: 
2 phenolic donor + H(2)O(2) = 2 phenoxyl radical of the donor + 2 H(2)O
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-105074 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lactoperoxidase Chain: A
Molecule details ›
Chain: A
Length: 595 amino acids
Theoretical weight: 67.57 KDa
Source organism: Capra hircus
UniProt:
  • Canonical: A0A452E9Y6 (Residues: 118-712; Coverage: 86%)
Gene name: LPO
Sequence domains: Animal haem peroxidase

Ligands and Environments


Cofactor: Ligand HEM 1 x HEM
8 bound ligands:
Ligand NAG 3 x NAG
Ligand CA 1 x CA
Ligand IOD 12 x IOD
Ligand EDO 4 x EDO
Ligand PEO 1 x PEO
Ligand OSM 8 x OSM
Ligand SCN 7 x SCN
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: P21
Unit cell:
a: 53.881Å b: 80.731Å c: 75.139Å
α: 90° β: 101.53° γ: 90°
R-values:
R R work R free
0.234 0.231 0.297

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