› 6npm

X-ray diffraction
1.6Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136654 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Epstein-Barr nuclear antigen 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 141 amino acids
Theoretical weight: 15.31 KDa
Source organism: Human herpesvirus 4 strain B95-8
Expression system: Escherichia coli
UniProt:
  • Canonical: P03211 (Residues: 471-607; Coverage: 21%)
Gene names: BKRF1, EBNA1
Sequence domains: Epstein Barr virus nuclear antigen-1, DNA-binding domain
Structure domains: Epstein Barr virus nuclear antigen-1, DNA-binding domain

Ligands and Environments

1 bound ligand:
Ligand KVD 1 x KVD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: P212121
Unit cell:
a: 59.458Å b: 67.951Å c: 69.546Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.145 0.143 0.17
Expression system: Escherichia coli

Quick links

Citations

18 review citations

Herpesvirus latency.
Cohen JI. (2020)
17 more

1 mention without citation

Structure-based design of small-molecule inhibitors of EBNA1 DNA binding blocks Epstein-Barr virus latent infection and tumor growth.
Messick et al. (2019)