› 6sdf

X-ray diffraction
2.5Å resolution

N-terminal SH3 domain of Grb2 protein

Released:
DOI: 10.2210/pdb6sdf/pdb
PDB entry 6sdf coloured by chain, front view.
PDB entry 6sdf coloured by chain, side view.
PDB entry 6sdf coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the SH3 domain of growth factor receptor-bound protein 2.
Bolgov A, Korban S, Luzik D, Zhemkov V, Kim M, Rogacheva O, Bezprozvanny I
Acta Crystallogr F Struct Biol Commun 76 263-270 (2020)
PMID: 32510467

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158852 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Growth factor receptor-bound protein 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 61 amino acids
Theoretical weight: 6.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P62993 (Residues: 2-59; Coverage: 27%)
Gene names: ASH, GRB2
Sequence domains: SH3 domain

Ligands and Environments

2 bound ligands:
Ligand MPD 6 x MPD
Ligand CL 3 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: OXFORD DIFFRACTION SUPERNOVA
Spacegroup: R3
Unit cell:
a: 97.731Å b: 97.731Å c: 51.032Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.162 0.16 0.21
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 citations in other articles

The structural basis of BCR-ABL recruitment of GRB2 in chronic myelogenous leukemia.
Liu et al. (2022)

5 mentions without citation

Exploration in the mechanism of fucosterol for the treatment of non-small cell lung cancer based on network pharmacology and molecular docking.
Li et al. (2021)
4 more