Function and Biology Details
Reaction catalysed:
S-adenosyl-L-methionine + adenine in mRNA = S-adenosyl-L-homocysteine + N(6)-methyladenine in mRNA
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183176 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
N(6)-adenosine-methyltransferase catalytic subunit METTL3
Molecule details ›
Chain: A
Length: 580 amino acids
Theoretical weight: 64.56 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains: MT-A70
Length: 580 amino acids
Theoretical weight: 64.56 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical:
Q86U44 (Residues: 1-580; Coverage: 100%)
Sequence domains: MT-A70
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14
Molecule details ›
Chain: B
Length: 456 amino acids
Theoretical weight: 52.23 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains: MT-A70
Length: 456 amino acids
Theoretical weight: 52.23 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: Q9HCE5 (Residues: 1-456; Coverage: 100%)
Sequence domains: MT-A70
