› 6v3i

X-ray diffraction
3.4Å resolution

K2P2.1(TREK-1)I110D:RuR bound channel structure

Released:
DOI: 10.2210/pdb6v3i/pdb
PDB entry 6v3i coloured by chain, front view.
PDB entry 6v3i coloured by chain, side view.
PDB entry 6v3i coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Polynuclear Ruthenium Amines Inhibit K2P Channels via a "Finger in the Dam" Mechanism.
Pope L, Lolicato M, Minor DL
Cell Chem Biol 27 511-524.e4 (2020)
PMID: 32059793

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161303 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Potassium channel subfamily K member 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 312 amino acids
Theoretical weight: 34.31 KDa
Source organism: Mus musculus
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P97438 (Residues: 35-338; Coverage: 71%)
Gene name: Kcnk2
Sequence domains: Ion channel

Ligands and Environments

7 bound ligands:
Ligand R2R 1 x R2R
Ligand D12 3 x D12
Ligand OCT 3 x OCT
Ligand HEX 1 x HEX
Ligand K 5 x K
Ligand LNK 1 x LNK
Ligand CD 3 x CD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P212121
Unit cell:
a: 67.945Å b: 120.303Å c: 127.818Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.278 0.276 0.328
Expression system: Komagataella pastoris

Quick links

Citations

6 review citations

On the molecular nature of large-pore channels.
Syrjanen et al. (2021)
5 more

2 mentions without citation

Structural Insights into the Mechanisms and Pharmacology of K2P Potassium Channels.
Natale et al. (2021)
1 more