› 6wjq

X-ray diffraction
2.71Å resolution

Crystal structure of WDR5 in complex with the WIN peptide of PDPK1

Released:
DOI: 10.2210/pdb6wjq/pdb
PDB entry 6wjq coloured by chain, front view.
PDB entry 6wjq coloured by chain, side view.
PDB entry 6wjq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of WDR5 in complex with the WIN peptide of PDPK1
zhao B, Fesik S
Cell Rep (2021)

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127512 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
WD repeat-containing protein 5 Chains: A, B
Molecule details ›
Chains: A, B
Length: 313 amino acids
Theoretical weight: 34.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61964 (Residues: 22-334; Coverage: 94%)
Gene names: BIG3, WDR5
Sequence domains: WD domain, G-beta repeat
3-phosphoinositide-dependent protein kinase 1 Chains: C, D
Molecule details ›
Chains: C, D
Length: 17 amino acids
Theoretical weight: 1.67 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: O15530 (Residues: 2-16; Coverage: 3%)
Gene names: PDK1, PDPK1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P21
Unit cell:
a: 54.518Å b: 47.228Å c: 118.965Å
α: 90° β: 90.92° γ: 90°
R-values:
R R work R free
0.226 0.223 0.252
Expression systems:
  • Escherichia coli
  • Not provided

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