› 6x2z

Electron Microscopy
3.03Å resolution

hEAAT3-OFS-Asp

Released:
DOI: 10.2210/pdb6x2z/pdb
PDB entry 6x2z coloured by chain, front view.
PDB entry 6x2z coloured by chain, side view.
PDB entry 6x2z coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structures of excitatory amino acid transporter 3 visualize coupled substrate, sodium, and proton binding and transport.
Qiu B, Matthies D, Fortea E, Yu Z, Boudker O
OpenAccess logo Sci Adv 7 (2021)
PMID: 33658209
Related structures: EMD-22014

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154931 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Excitatory amino acid transporter 3 Chain: A
Molecule details ›
Chain: A
Length: 526 amino acids
Theoretical weight: 57.28 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P43005 (Residues: 1-524; Coverage: 100%)
Gene names: EAAC1, EAAT3, HEAAC1, SLC1A1
Sequence domains: Sodium:dicarboxylate symporter family

Ligands and Environments

2 bound ligands:
Ligand ASP 1 x ASP
Ligand NA 3 x NA
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.03Å
Relevant EMDB volumes: EMD-22014
Expression system: Homo sapiens

Quick links

Citations

2 review citations

A Medicinal Chemistry Perspective on Excitatory Amino Acid Transporter 2 Dysfunction in Neurodegenerative Diseases.
Fontana et al. (2023)
1 more

2 mentions without citation

New and Emerging Research on Solute Carrier and ATP Binding Cassette Transporters in Drug Discovery and Development: Outlook From the International Transporter Consortium.
Giacomini et al. (2022)
1 more